TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions
Identifieur interne : 003C65 ( Main/Exploration ); précédent : 003C64; suivant : 003C66TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions
Auteurs : Michael D. Gallagher [États-Unis] ; Eunran Suh [États-Unis] ; Murray Grossman [États-Unis] ; Lauren Elman [États-Unis] ; Leo Mccluskey [États-Unis] ; John C. Van Swieten [Pays-Bas] ; Safa Al-Sarraj [Royaume-Uni] ; Manuela Neumann [Allemagne] ; Ellen Gelpi [Espagne] ; Bernardino Ghetti [États-Unis] ; Jonathan D. Rohrer [Royaume-Uni] ; Glenda Halliday [Australie] ; Christine Van Broeckhoven [Belgique] ; Danielle Seilhean [France] ; Pamela J. Shaw [Royaume-Uni] ; Matthew P. Frosch [États-Unis] ; John Q. Trojanowski [États-Unis] ; Virginia M. Y. Lee [États-Unis] ; Vivianna Van Deerlin [États-Unis] ; Alice S. Chen-Plotkin [États-Unis]Source :
- Acta neuropathologica [ 0001-6322 ] ; 2014.
Abstract
Hexanucleotide repeat expansions in chromosome 9 open reading frame 72 (
Url:
DOI: 10.1007/s00401-013-1239-x
PubMed: 24442578
PubMed Central: 4003885
Affiliations:
- Allemagne, Australie, Belgique, Espagne, France, Pays-Bas, Royaume-Uni, États-Unis
- Angleterre, Bade-Wurtemberg, District de Tübingen, Grand Londres, Hollande-Méridionale, Hollande-Septentrionale, Indiana, Massachusetts, Pennsylvanie
- Amsterdam, Londres, Rotterdam, Tübingen
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001D42
- to stream Pmc, to step Curation: 001B98
- to stream Pmc, to step Checkpoint: 001782
- to stream Ncbi, to step Merge: 001728
- to stream Ncbi, to step Curation: 001728
- to stream Ncbi, to step Checkpoint: 001728
- to stream Main, to step Merge: 003D16
- to stream Main, to step Curation: 003C65
Le document en format XML
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is a genetic modifier of frontotemporal lobar degeneration with <italic>C9orf72</italic>
hexanucleotide repeat expansions</title>
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<author><name sortKey="Van Swieten, John C" sort="Van Swieten, John C" uniqKey="Van Swieten J" first="John C." last="Van Swieten">John C. Van Swieten</name>
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<author><name sortKey="Al Sarraj, Safa" sort="Al Sarraj, Safa" uniqKey="Al Sarraj S" first="Safa" last="Al-Sarraj">Safa Al-Sarraj</name>
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<author><name sortKey="Rohrer, Jonathan D" sort="Rohrer, Jonathan D" uniqKey="Rohrer J" first="Jonathan D." last="Rohrer">Jonathan D. Rohrer</name>
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<author><name sortKey="Halliday, Glenda" sort="Halliday, Glenda" uniqKey="Halliday G" first="Glenda" last="Halliday">Glenda Halliday</name>
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<author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name>
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<author><name sortKey="Seilhean, Danielle" sort="Seilhean, Danielle" uniqKey="Seilhean D" first="Danielle" last="Seilhean">Danielle Seilhean</name>
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<author><name sortKey="Shaw, Pamela J" sort="Shaw, Pamela J" uniqKey="Shaw P" first="Pamela J." last="Shaw">Pamela J. Shaw</name>
<affiliation wicri:level="1"><nlm:aff id="A16">University of Sheffield, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University of Sheffield</wicri:regionArea>
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<author><name sortKey="Frosch, Matthew P" sort="Frosch, Matthew P" uniqKey="Frosch M" first="Matthew P." last="Frosch">Matthew P. Frosch</name>
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<author><name sortKey="Trojanowski, John Q" sort="Trojanowski, John Q" uniqKey="Trojanowski J" first="John Q." last="Trojanowski">John Q. Trojanowski</name>
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<placeName><region type="state">Pennsylvanie</region>
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<author><name sortKey="Lee, Virginia M Y" sort="Lee, Virginia M Y" uniqKey="Lee V" first="Virginia M. Y." last="Lee">Virginia M. Y. Lee</name>
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<placeName><region type="state">Pennsylvanie</region>
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<author><name sortKey="Van Deerlin, Vivianna" sort="Van Deerlin, Vivianna" uniqKey="Van Deerlin V" first="Vivianna" last="Van Deerlin">Vivianna Van Deerlin</name>
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<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Chen Plotkin, Alice S" sort="Chen Plotkin, Alice S" uniqKey="Chen Plotkin A" first="Alice S." last="Chen-Plotkin">Alice S. Chen-Plotkin</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia</wicri:cityArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>TMEM106B</italic>
is a genetic modifier of frontotemporal lobar degeneration with <italic>C9orf72</italic>
hexanucleotide repeat expansions</title>
<author><name sortKey="Gallagher, Michael D" sort="Gallagher, Michael D" uniqKey="Gallagher M" first="Michael D." last="Gallagher">Michael D. Gallagher</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Cell & Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Cell & Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Suh, Eunran" sort="Suh, Eunran" uniqKey="Suh E" first="Eunran" last="Suh">Eunran Suh</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
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<wicri:cityArea>Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia</wicri:cityArea>
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<author><name sortKey="Grossman, Murray" sort="Grossman, Murray" uniqKey="Grossman M" first="Murray" last="Grossman">Murray Grossman</name>
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<placeName><region type="state">Pennsylvanie</region>
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<author><name sortKey="Elman, Lauren" sort="Elman, Lauren" uniqKey="Elman L" first="Lauren" last="Elman">Lauren Elman</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Mccluskey, Leo" sort="Mccluskey, Leo" uniqKey="Mccluskey L" first="Leo" last="Mccluskey">Leo Mccluskey</name>
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<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Van Swieten, John C" sort="Van Swieten, John C" uniqKey="Van Swieten J" first="John C." last="Van Swieten">John C. Van Swieten</name>
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<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
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</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A5">Alzheimercenter Vumc, Boelelaan 1118, Amsterdam</nlm:aff>
<country>Pays-Bas</country>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
<wicri:orgArea>Alzheimercenter Vumc, Boelelaan 1118</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Al Sarraj, Safa" sort="Al Sarraj, Safa" uniqKey="Al Sarraj S" first="Safa" last="Al-Sarraj">Safa Al-Sarraj</name>
<affiliation wicri:level="3"><nlm:aff id="A6">King’s College Hospital, London</nlm:aff>
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<placeName><settlement type="city">Londres</settlement>
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</placeName>
<wicri:orgArea>King’s College Hospital</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Neumann, Manuela" sort="Neumann, Manuela" uniqKey="Neumann M" first="Manuela" last="Neumann">Manuela Neumann</name>
<affiliation wicri:level="3"><nlm:aff id="A7">University of Tübingen, Calwerstr. 3, 72072 Tübingen, Germany</nlm:aff>
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<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
<affiliation><nlm:aff id="A8">German Center for Neurodegenerative Diseases (DZNE)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gelpi, Ellen" sort="Gelpi, Ellen" uniqKey="Gelpi E" first="Ellen" last="Gelpi">Ellen Gelpi</name>
<affiliation wicri:level="1"><nlm:aff id="A9">Neurological Tissue Bank of the Biobank-Hospital Clinic-Insitut d’Investigacions Biomèdiques August Pi i Sunyer, Facultad de Medicina, c/Casanova 143, planta 0, ala sur. 08036 Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Neurological Tissue Bank of the Biobank-Hospital Clinic-Insitut d’Investigacions Biomèdiques August Pi i Sunyer, Facultad de Medicina, c/Casanova 143, planta 0, ala sur. 08036 Barcelona</wicri:regionArea>
<wicri:noRegion>ala sur. 08036 Barcelona</wicri:noRegion>
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<author><name sortKey="Ghetti, Bernardino" sort="Ghetti, Bernardino" uniqKey="Ghetti B" first="Bernardino" last="Ghetti">Bernardino Ghetti</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Indiana</region>
</placeName>
<wicri:cityArea>Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rohrer, Jonathan D" sort="Rohrer, Jonathan D" uniqKey="Rohrer J" first="Jonathan D." last="Rohrer">Jonathan D. Rohrer</name>
<affiliation wicri:level="3"><nlm:aff id="A11">Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Halliday, Glenda" sort="Halliday, Glenda" uniqKey="Halliday G" first="Glenda" last="Halliday">Glenda Halliday</name>
<affiliation wicri:level="1"><nlm:aff id="A12">Neuroscience Research Australia, Barker St, Randwick, NSW 2031, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Neuroscience Research Australia, Barker St, Randwick, NSW 2031</wicri:regionArea>
<wicri:noRegion>NSW 2031</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A13">Faculty of Medicine, University of New South Wales, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Faculty of Medicine, University of New South Wales</wicri:regionArea>
<wicri:noRegion>University of New South Wales</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name>
<affiliation wicri:level="1"><nlm:aff id="A14">Neurodegenerative Brain Disease Group, Department of Molecular Genetics, VIB, Universiteitsplein 1, 2610 Antwerpen, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Neurodegenerative Brain Disease Group, Department of Molecular Genetics, VIB, Universiteitsplein 1, 2610 Antwerpen</wicri:regionArea>
<wicri:noRegion>2610 Antwerpen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Seilhean, Danielle" sort="Seilhean, Danielle" uniqKey="Seilhean D" first="Danielle" last="Seilhean">Danielle Seilhean</name>
<affiliation wicri:level="1"><nlm:aff id="A15">University Pierre et Marie Curie (UPMC)-Sorbonne University, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Pierre et Marie Curie (UPMC)-Sorbonne University</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Shaw, Pamela J" sort="Shaw, Pamela J" uniqKey="Shaw P" first="Pamela J." last="Shaw">Pamela J. Shaw</name>
<affiliation wicri:level="1"><nlm:aff id="A16">University of Sheffield, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University of Sheffield</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Frosch, Matthew P" sort="Frosch, Matthew P" uniqKey="Frosch M" first="Matthew P." last="Frosch">Matthew P. Frosch</name>
<affiliation wicri:level="2"><nlm:aff id="A17">Massachusetts Alzheimer’s Disease Research Center, Harvard Medical School, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Massachusetts Alzheimer’s Disease Research Center, Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Trojanowski, John Q" sort="Trojanowski, John Q" uniqKey="Trojanowski J" first="John Q." last="Trojanowski">John Q. Trojanowski</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lee, Virginia M Y" sort="Lee, Virginia M Y" uniqKey="Lee V" first="Virginia M. Y." last="Lee">Virginia M. Y. Lee</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Van Deerlin, Vivianna" sort="Van Deerlin, Vivianna" uniqKey="Van Deerlin V" first="Vivianna" last="Van Deerlin">Vivianna Van Deerlin</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Chen Plotkin, Alice S" sort="Chen Plotkin, Alice S" uniqKey="Chen Plotkin A" first="Alice S." last="Chen-Plotkin">Alice S. Chen-Plotkin</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Acta neuropathologica</title>
<idno type="ISSN">0001-6322</idno>
<idno type="eISSN">1432-0533</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Hexanucleotide repeat expansions in chromosome 9 open reading frame 72 (<italic>C9orf72)</italic>
have recently been linked to frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS), and may be the most common genetic cause of both neurodegenerative diseases. Genetic variants at <italic>TMEM106B</italic>
influence risk for the most common neuropathological subtype of FTLD, characterized by inclusions of TAR DNA binding protein of 43kDa (FTLD-TDP). Previous reports have shown that <italic>TMEM106B</italic>
is a genetic modifier of FTLD-TDP caused by progranulin (<italic>GRN</italic>
) mutations, with the major (risk) allele of rs1990622 associating with earlier age at onset of disease. Here we report that rs1990622 genotype affects age at death in a single-site discovery cohort of FTLD patients with <italic>C9orf72</italic>
expansions (n=14), with the major allele correlated with later age at death (p=0.024). We replicate this modifier effect in a 30-site international neuropathological cohort of FTLD-TDP patients with <italic>C9orf72</italic>
expansions (n=75), again finding that the major allele associates with later age at death (p=0.016), as well as later age at onset (p=0.019). In contrast, <italic>TMEM106B</italic>
genotype does not affect age at onset or death in 241 FTLD-TDP cases negative for <italic>GRN</italic>
mutations or <italic>C9orf72</italic>
expansions. Thus, <italic>TMEM106B</italic>
is a genetic modifier of FTLD with <italic>C9orf72</italic>
expansions. Intriguingly, the genotype that confers increased risk for developing FTLD-TDP (major, or T, allele of rs1990622) is associated with later age at onset and death in <italic>C9orf72</italic>
expansion carriers, providing an example of sign epistasis in human neurodegenerative disease.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Belgique</li>
<li>Espagne</li>
<li>France</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Bade-Wurtemberg</li>
<li>District de Tübingen</li>
<li>Grand Londres</li>
<li>Hollande-Méridionale</li>
<li>Hollande-Septentrionale</li>
<li>Indiana</li>
<li>Massachusetts</li>
<li>Pennsylvanie</li>
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<li>Londres</li>
<li>Rotterdam</li>
<li>Tübingen</li>
</settlement>
</list>
<tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Gallagher, Michael D" sort="Gallagher, Michael D" uniqKey="Gallagher M" first="Michael D." last="Gallagher">Michael D. Gallagher</name>
</region>
<name sortKey="Chen Plotkin, Alice S" sort="Chen Plotkin, Alice S" uniqKey="Chen Plotkin A" first="Alice S." last="Chen-Plotkin">Alice S. Chen-Plotkin</name>
<name sortKey="Elman, Lauren" sort="Elman, Lauren" uniqKey="Elman L" first="Lauren" last="Elman">Lauren Elman</name>
<name sortKey="Frosch, Matthew P" sort="Frosch, Matthew P" uniqKey="Frosch M" first="Matthew P." last="Frosch">Matthew P. Frosch</name>
<name sortKey="Gallagher, Michael D" sort="Gallagher, Michael D" uniqKey="Gallagher M" first="Michael D." last="Gallagher">Michael D. Gallagher</name>
<name sortKey="Ghetti, Bernardino" sort="Ghetti, Bernardino" uniqKey="Ghetti B" first="Bernardino" last="Ghetti">Bernardino Ghetti</name>
<name sortKey="Grossman, Murray" sort="Grossman, Murray" uniqKey="Grossman M" first="Murray" last="Grossman">Murray Grossman</name>
<name sortKey="Lee, Virginia M Y" sort="Lee, Virginia M Y" uniqKey="Lee V" first="Virginia M. Y." last="Lee">Virginia M. Y. Lee</name>
<name sortKey="Mccluskey, Leo" sort="Mccluskey, Leo" uniqKey="Mccluskey L" first="Leo" last="Mccluskey">Leo Mccluskey</name>
<name sortKey="Suh, Eunran" sort="Suh, Eunran" uniqKey="Suh E" first="Eunran" last="Suh">Eunran Suh</name>
<name sortKey="Trojanowski, John Q" sort="Trojanowski, John Q" uniqKey="Trojanowski J" first="John Q." last="Trojanowski">John Q. Trojanowski</name>
<name sortKey="Van Deerlin, Vivianna" sort="Van Deerlin, Vivianna" uniqKey="Van Deerlin V" first="Vivianna" last="Van Deerlin">Vivianna Van Deerlin</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Van Swieten, John C" sort="Van Swieten, John C" uniqKey="Van Swieten J" first="John C." last="Van Swieten">John C. Van Swieten</name>
</region>
<name sortKey="Van Swieten, John C" sort="Van Swieten, John C" uniqKey="Van Swieten J" first="John C." last="Van Swieten">John C. Van Swieten</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Al Sarraj, Safa" sort="Al Sarraj, Safa" uniqKey="Al Sarraj S" first="Safa" last="Al-Sarraj">Safa Al-Sarraj</name>
</region>
<name sortKey="Rohrer, Jonathan D" sort="Rohrer, Jonathan D" uniqKey="Rohrer J" first="Jonathan D." last="Rohrer">Jonathan D. Rohrer</name>
<name sortKey="Shaw, Pamela J" sort="Shaw, Pamela J" uniqKey="Shaw P" first="Pamela J." last="Shaw">Pamela J. Shaw</name>
</country>
<country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Neumann, Manuela" sort="Neumann, Manuela" uniqKey="Neumann M" first="Manuela" last="Neumann">Manuela Neumann</name>
</region>
</country>
<country name="Espagne"><noRegion><name sortKey="Gelpi, Ellen" sort="Gelpi, Ellen" uniqKey="Gelpi E" first="Ellen" last="Gelpi">Ellen Gelpi</name>
</noRegion>
</country>
<country name="Australie"><noRegion><name sortKey="Halliday, Glenda" sort="Halliday, Glenda" uniqKey="Halliday G" first="Glenda" last="Halliday">Glenda Halliday</name>
</noRegion>
<name sortKey="Halliday, Glenda" sort="Halliday, Glenda" uniqKey="Halliday G" first="Glenda" last="Halliday">Glenda Halliday</name>
</country>
<country name="Belgique"><noRegion><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name>
</noRegion>
</country>
<country name="France"><noRegion><name sortKey="Seilhean, Danielle" sort="Seilhean, Danielle" uniqKey="Seilhean D" first="Danielle" last="Seilhean">Danielle Seilhean</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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